Interested applicants are invited to apply directly at the NUS Career Portal .
Your application will be processed only if you apply via the NUS Career Portal .
We regret that only shortlisted candidates will be notified.
Join Professor Patani's distinguished laboratory within the Life Sciences Institute's Neurobiology division to advance research in motor neuron disease, particularly Amyotrophic Lateral Sclerosis (ALS).
This pivotal role centres on elucidating the molecular and cellular mechanisms that drive ALS pathogenesis by leveraging cutting-edge methodologies, including the use of patient-derived induced pluripotent stem cells (iPSCs).
The successful candidate will be instrumental in dissecting disease mechanisms across various relevant neural cell types, such as motor neurons, astrocytes, and microglia, thereby contributing to transformative insights in neurodegenerative disease biology.
The Research Fellow will spearhead a strategically designed research programme focused on understanding the nexus between genomic instability and altered RNA metabolism in ALS.
This involves close collaboration with interdisciplinary teams, including experimental biologists and computational data scientists, to design and execute sophisticated experiments.
The role entails employing state-of-the-art molecular techniques alongside innovative sequencing technologies, facilitated by partnership with the Boulton Laboratory at the Francis Crick Institute, to investigate the functional interplay within pathological pathways.
Ideal candidates will possess a PhD in Biomedical Sciences, Neuroscience, or a closely related discipline, complemented by comprehensive expertise in ALS research.
Profound familiarity with human iPSC technology, including differentiation into neural subtypes and experience with mouse models of ALS, is essential.
Candidates should demonstrate proficiency in advanced molecular biology techniques and be adept at analyzing high-throughput datasets such as RNA sequencing and imaging data.
Experience working with human post-mortem tissue to corroborate experimental findings is highly desirable, as is competence in computational biology through coding skills tailored to bioinformatics analyses.
A track record of supervising postgraduate students or early career researchers is important, evidencing leadership and mentoring capabilities.
Applicants must showcase a robust publication history in peer-reviewed, high-impact journals, coupled with a recognized independent research profile at national and international levels.
Evidence of active engagement in the scientific community via conference presentations and collaborative projects will be considered an asset.
We are seeking candidates who are passionate about contributing to world-leading research in molecular neuroscience and dedicated to advancing understanding of ALS to ultimately inform therapeutic innovation.