The Genome Institute of Singapore (GIS) is the national flagship for genomic sciences, driving cutting-edge research at the intersection of biology, engineering, and medicine.
This position is offered in the Laboratory of AI in Genomics, led by Prof.
Mile Sikic, which uses advanced bioinformatics and deep learning approaches to develop next-generation models for genomic data analysis.
We are group a of computer scientist with a mission to improve healthcare using advance deep learning models.
Located in the heart of Singapore's thriving biomedical hub, GIS offers a dynamic and collaborative environment, with close ties to world-class universities (NUS and NTU), pharmaceutical companies, and biotech start-ups.
Joining our team means working on transformative projects with real-world impact, while benefiting from Singapore's vibrant research ecosystem and strong support for innovation.
Project background
The AI in drug discovery (AIDD) project focuses on developing innovative tools and technologies to accelerate drug discovery, with a particular emphasis on unlocking new druggable spaces, such as RNA-targeting molecules, for example.
With AI-driven strategies, AIDD aims to accelerate target identification to lead discovery while also advancing novel small molecules and other therapeutic modalities for next-generation drug development.
This project aims to develop novel deep learning methods for RNA tertiary structure prediction, inspired by the breakthroughs of AlphaFold in protein structure modeling.
We plan to design a robust framework that incorporates RiNALMo, our state-of-the-art RNA language model [].
Additionally, we will investigate the integration of chemical reactivity measurements to enhance accuracy.
Such data, closely tied to RNA's 3D structure, offers valuable information on secondary structure elements, base-pairing, and conformational flexibility.
By leveraging these inputs, our approach seeks to bridge the gap between computational and experimental methods, with significant implications for RNA drug discovery.
Job description
We are looking for a highly motivated postdoctoral researcher to:
·Develop deep learning-based models for RNA structure prediction
·Analyze chemical reactivity experimental data
·Incorporate chemical reactivity experimental data into the structure prediction pipeline
·Run large-scale training on high-performance computing infrastructure
·Perform model finetuning and hyperparameter optimization
·Evaluate models on experimental data
Profile
We welcome applications from candidates with:
·A PhD in computer science, computational biology, computational chemistry, applied mathematics, physics, or a related field
·Proven experience in deep learning research and development
·publication record at top-tier AI conferences (e.g., NeurIPS, ICLR, ICML, CVPR, ICCV, ACL, etc)
·Strong experience in Python programming and solid software engineering skills
·Experience with biomolecules and/or high-performance computing is a plus
·Interest in biology, biomolecules, or genomics (prior expertise not required)
·A structured, independent, proactive and collaborative working style
We offer
·A fully funded position with an internationally competitive salary
·Professional development opportunities, including support for grant applications and participation in conferences and workshops
·Access to state-of-the-art research infrastructure, including NSCC's high-performance computing clusters
·A dynamic, interdisciplinary, and collaborative research environment
·The position is initially offered for one year, with the possibility of renewal.
How to apply
We look forward to receiving your application with the following documents:
·Letter of Motivation
·CV
·Diplomas & Transcripts
We accept applications submitted through our online application portal or via email directed to Prof.
Sikic at mile_sikic@a-star.edu.sg.