Know ATS Score
CV/Résumé Score
  • Expertini Resume Scoring: Our Semantic Matching Algorithm evaluates your CV/Résumé before you apply for this job role: Scientist, Bioconjugation & Targeted RNA Delivery.
Singapore Jobs Expertini

Urgent! Scientist, Bioconjugation & Targeted RNA Delivery Job Opening In Singapore, Singapore – Now Hiring A*STAR Research

Scientist, Bioconjugation & Targeted RNA Delivery



Job description

Posting Date : 18 Aug 2025 | Closing Date :17 Oct 2025

Organization: Platform Technology

Job Type: Full Time

About NATi:

The Nucleic Acid Therapeutics Initiative (NATi), hosted by A*STAR, is Singapore's national platform dedicated to advancing RNA-based medicines and revolutionizing drug and vaccine development.

NATi's mission is to establish Singapore as a globally recognized hub of excellence in nucleic acid therapeutics research, clinical translation, and commercialization.

NATi focuses on key RNA modalities such as antisense oligonucleotides (ASOs), small interfering RNA (siRNA), and messenger RNA (mRNA).

To drive this vision, NATi is building a biotech-like translational engine focused on asset and technology development spanning discovery to clinical development.

We are actively seeking passionate and committed RNA scientists with deep translational expertise to join us in advancing the next generation of RNA-based therapeutics.


Position Overview

We seek a highly motivated, results-driven, bench-level scientist with strong expertise in bioconjugation and targeted delivery to support the development of ligand-oligonucleotide conjugates (LOCs) for extrahepatic RNA delivery.

This role is focused on hands-on experimental work and project leadership, contributing directly to to the design, synthesis, and characterization of LOCs that efficiently target tissues such as skeletal/cardiac muscles, adipose tissues, and ocular compartments with high selectivity.

The successful candidate will lead individual projects and collaborate cross-functionally to identify and optimize LOCs with high tissue/cell selectivity and functional delivery.


Key Responsibilities

Design and execute conjugation strategies to generate LOCs with optimized delivery profiles.

Perform hands-on synthesis, purification, and analytical characterization of LOCs using diverse conjugation chemistries and linker designs.

Collaborate closely with oligonucleotide chemists, biologists, and pharmacologists to evaluate LOCs in vitro and in vivo.

Support CRO coordination and reagent sourcing for ligand libraries and conjugation reagents.

Ensure reproducibility and analytical rigor across experimental workflows

Maintain high-quality documentation of experimental procedures, results, and data interpretation.

Contribute to innovation and IP generation through novel conjugation approaches and delivery strategies.

Present findings in internal meetings and contribute to technical reports, publications, and patent filings.


Qualifications & Experience

A doctorate degree in Chemistry, Chemical Biology, Organic/Medicinal Chemistry, or a related field.

A minimum of 2-6 years of relevant industry experience in bioconjugation chemistry applied to LOCs, ADCs, PDCs, or targeted delivery systems

Hands-on experience establishing conjugation chemistries (e.g., Click, lysine-/cysteine-based coupling, enzymatic ligation, stimuli-sensitive linkers) workflows for development of LOCs.

Hands-on experience with multiscale purification methods (e.g., preparative RP-HPLC, affinity, ion-exchange, hydrophobic interaction, and size exclusion chromatography, tangential flow filtration) and the associated instruments.

Deep understanding of analytical techniques (e.g., LC-MS, LC-HRMS, CE-SDS, DSC, HIC, NMR) coupled with hands-on experience developing analytical workflows for robust characterization of LOCs.

Experience coordinating with CROs and cross-functional program leadership.

Demonstrated innovation through IP, publications, IND filings, or other public disclosures.

Excellent organizational, interpersonal, and verbal/written communication skills.


Global Recruitment & Competitive Compensation

NATi is conducting a global search for top-tier talent in RNA therapeutics.

We welcome applications from leading pharmaceuticals scientists and biotech innovators worldwide.

This role provides a highly competitive compensation package aligned with global industry standards, including attractive benefits and long-term career growth opportunities within Singapore's thriving biomedical innovation ecosystem.

Join us in shaping the future of RNA-based medicines and establishing Singapore as a world-class hub for nucleic acid therapeutics.

The above eligibility criteria are not exhaustive.

A*STAR may include additional selection criteria based on its prevailing recruitment policies.

These policies may be amended from time to time without notice.

We regret that only shortlisted candidates will be notified.

#J-18808-Ljbffr


Required Skill Profession

Research, Development And Laboratory



Your Complete Job Search Toolkit

✨ Smart • Intelligent • Private • Secure

Start Using Our Tools

Join thousands of professionals who've advanced their careers with our platform

Rate or Report This Job
If you feel this job is inaccurate or spam kindly report to us using below form.
Please Note: This is NOT a job application form.


    Unlock Your Scientist Bioconjugation Potential: Insight & Career Growth Guide


  • Real-time Scientist Bioconjugation Jobs Trends in Singapore, Singapore (Graphical Representation)

    Explore profound insights with Expertini's real-time, in-depth analysis, showcased through the graph below. This graph displays the job market trends for Scientist Bioconjugation in Singapore, Singapore using a bar chart to represent the number of jobs available and a trend line to illustrate the trend over time. Specifically, the graph shows 1601 jobs in Singapore and 1521 jobs in Singapore. This comprehensive analysis highlights market share and opportunities for professionals in Scientist Bioconjugation roles. These dynamic trends provide a better understanding of the job market landscape in these regions.

  • Are You Looking for Scientist, Bioconjugation & Targeted RNA Delivery Job?

    Great news! is currently hiring and seeking a Scientist, Bioconjugation & Targeted RNA Delivery to join their team. Feel free to download the job details.

    Wait no longer! Are you also interested in exploring similar jobs? Search now: .

  • The Work Culture

    An organization's rules and standards set how people should be treated in the office and how different situations should be handled. The work culture at A*STAR Research adheres to the cultural norms as outlined by Expertini.

    The fundamental ethical values are:
    • 1. Independence
    • 2. Loyalty
    • 3. Impartiality
    • 4. Integrity
    • 5. Accountability
    • 6. Respect for human rights
    • 7. Obeying Singapore laws and regulations
  • What Is the Average Salary Range for Scientist, Bioconjugation & Targeted RNA Delivery Positions?

    The average salary range for a varies, but the pay scale is rated "Standard" in Singapore. Salary levels may vary depending on your industry, experience, and skills. It's essential to research and negotiate effectively. We advise reading the full job specification before proceeding with the application to understand the salary package.

  • What Are the Key Qualifications for Scientist, Bioconjugation & Targeted RNA Delivery?

    Key qualifications for Scientist, Bioconjugation & Targeted RNA Delivery typically include Research, Development And Laboratory and a list of qualifications and expertise as mentioned in the job specification. Be sure to check the specific job listing for detailed requirements and qualifications.

  • How Can I Improve My Chances of Getting Hired for Scientist, Bioconjugation & Targeted RNA Delivery?

    To improve your chances of getting hired for Scientist, Bioconjugation & Targeted RNA Delivery, consider enhancing your skills. Check your CV/Résumé Score with our free Tool. We have an in-built Resume Scoring tool that gives you the matching score for each job based on your CV/Résumé once it is uploaded. This can help you align your CV/Résumé according to the job requirements and enhance your skills if needed.

  • Interview Tips for Scientist, Bioconjugation & Targeted RNA Delivery Job Success
    A*STAR Research interview tips for Scientist, Bioconjugation & Targeted RNA Delivery

    Here are some tips to help you prepare for and ace your job interview:

    Before the Interview:
    • Research: Learn about the A*STAR Research's mission, values, products, and the specific job requirements and get further information about
    • Other Openings
    • Practice: Prepare answers to common interview questions and rehearse using the STAR method (Situation, Task, Action, Result) to showcase your skills and experiences.
    • Dress Professionally: Choose attire appropriate for the company culture.
    • Prepare Questions: Show your interest by having thoughtful questions for the interviewer.
    • Plan Your Commute: Allow ample time to arrive on time and avoid feeling rushed.
    During the Interview:
    • Be Punctual: Arrive on time to demonstrate professionalism and respect.
    • Make a Great First Impression: Greet the interviewer with a handshake, smile, and eye contact.
    • Confidence and Enthusiasm: Project a positive attitude and show your genuine interest in the opportunity.
    • Answer Thoughtfully: Listen carefully, take a moment to formulate clear and concise responses. Highlight relevant skills and experiences using the STAR method.
    • Ask Prepared Questions: Demonstrate curiosity and engagement with the role and company.
    • Follow Up: Send a thank-you email to the interviewer within 24 hours.
    Additional Tips:
    • Be Yourself: Let your personality shine through while maintaining professionalism.
    • Be Honest: Don't exaggerate your skills or experience.
    • Be Positive: Focus on your strengths and accomplishments.
    • Body Language: Maintain good posture, avoid fidgeting, and make eye contact.
    • Turn Off Phone: Avoid distractions during the interview.
    Final Thought:

    To prepare for your Scientist, Bioconjugation & Targeted RNA Delivery interview at A*STAR Research, research the company, understand the job requirements, and practice common interview questions.

    Highlight your leadership skills, achievements, and strategic thinking abilities. Be prepared to discuss your experience with HR, including your approach to meeting targets as a team player. Additionally, review the A*STAR Research's products or services and be prepared to discuss how you can contribute to their success.

    By following these tips, you can increase your chances of making a positive impression and landing the job!

  • How to Set Up Job Alerts for Scientist, Bioconjugation & Targeted RNA Delivery Positions

    Setting up job alerts for Scientist, Bioconjugation & Targeted RNA Delivery is easy with Singapore Jobs Expertini. Simply visit our job alerts page here, enter your preferred job title and location, and choose how often you want to receive notifications. You'll get the latest job openings sent directly to your email for FREE!