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Scientist, Laboratory of Chemical Biology and Functional Genomics (GIS) Job Opening In Singapore, Singapore – Now Hiring A*STAR

Scientist, Laboratory of Chemical Biology and Functional Genomics (GIS)

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Job description

The Yu Lab has an opening position for Scientist recently and are looking for a highly motivated Scientist to join our team and contribute to innovative RNA-targeted therapeutic discovery.


We are a chemical biology lab dedicated to translational research targeting cellular nucleic acids.

This project is to engineer antisense oligonucleotides (ASOs) for gene-selective regulation, paving the way for precision medicine.

By leveraging cutting-edge gene-targeting strategies, structural biology, sequencing technologies, and computational approaches, we aim to unlock RNA as precise therapeutic target, addressing diseases linked to genomic dysregulation and undruggable pathways.


Contract length: 13-month contract for the first instance


Responsibilities:

  • Lead the design and optimize RNA-targeting strategies in cells.

  • Lead in designing and conducting experiments related to CRISPR, small-molecule screening, and ASO development.

  • Perform molecular biology experiments, including CRISPR-based gene regulation, plasmid construction, stable cell line establishment, and RNA-seq library preparation.

  • Maintain lab operations, including reagent preparation, consumable ordering, budget tracking, and equipment maintenance.

  • Engage in literature reviews, research discussions, and collaborative projects.

  • Ensure project milestones are met and contribute to manuscript preparation.

  • Requirements:

  • PhD degree in Biological Sciences, Chemical Biology, or related fields.

  • Experience in ASO design, molecular biology, cell culture, RNA biology, CRISPR, or sequencing technologies.

  • Strong organizational skills and a positive, eager-to-learn attitude.

  • Ability to work both independently and collaboratively in a fast-paced research environment.

  • Application Details


    For inquiries or to apply, please email your CV and brief research interest to Zutao Yu (yuzt@a-star.edu.sg), with email title ?Scientist application_A*STAR?.

    More information about the lab can be found online: and https://www.a-star.edu.sg/gis/our-people/faculty-staff/members/yu-zutao .


    Why Join Us?


    The Genome Institute of Singapore (GIS), A*STAR is the national flagship program for genomic sciences in Singapore, with a mission to use genomics to improve public health and drive biomedical innovation.

    GIS offers a highly competitive remuneration package and relocation assistance.

    Singapore is a vibrant, cosmopolitan city-state at the heart of Asia, known for its excellent quality of life, world-class research infrastructure, and strong government support for scientific innovation.


    Join us in advancing RNA and DNA-targeted therapeutics and making an impact in functional genomic medicine!

    Required Skill Profession

    Life Scientists


    • Job Details

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