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Scientist / Senior Scientist (LEE lab), A*SRL Job Opening In Singapore, Singapore – Now Hiring A*STAR


Job description

We are seeking a highly motivated and skilled Scientist or Senior Scientist to join our dynamic research team at A*STAR.

The ideal candidate will have a strong background in mouse disease models, cell and molecular biology, developmental biology, physiology, or related disciplines, and will play a key role in a well-funded translational research project aimed at developing a novel therapeutic asset, with the goal of achieving spinoff or licensing readiness within 1-2 years.

This role provides a unique opportunity to bridge basic science and therapeutic innovation in a collaborative, fast-paced environment with strong institutional support for commercialization.

Key Responsibilities


  • Design and execute in vivo mouse experiments, including animal handling, compound administration (e.g., IP/IV/SC), and tissue harvesting.


  • Isolate primary cells from mouse or human tissues, cell culture of primary or immortalised mammalian cells.

  • Engineering of stable cell lines by designing, generating, and using lentivirus or other transgenesis systems.

  • Perform comprehensive tissue and cell analyses using:

    Histological techniques (e.g., fixation, embedding, sectioning, histological staining, immunohistochemistry)

    Biochemical assays (e.g., Western blotting, ELISA, enzymatic assays, serum biochemistry) Molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, molecular cloning, and gene expression analysis.

    Bulk and single cell RNA sequencing Microscopy (e.g., fluorescence, confocal, and brightfield imaging)
  • Design and validate loss-of-function strategies (e.g., RNAi, CRISPR-Cas9) for gene perturbation in vitro and in vivo.

  • Analyze and interpret data.

  • Maintain thorough laboratory records that will withstand regulatory scrutiny.

  • Prepare technical reports, presentations, and manuscripts that may eventually contribute to regulatory applications (e.g. IND) and peer reviewed publications.

  • Collaborate across multidisciplinary teams, including scientific, translational, and commercialization partners.


  • Job Requirement

  • Ph.D. in Cell/Molecular Biology, Developmental Biology, Physiology, Genetics, or a related field.

  • Demonstrated hands-on experience with mouse models, including compound dosing and tissue dissection, is required.

  • Proficiency in primary cell isolation and culture, including from mouse or human tissues.

  • Strong technical skills in histology, biochemistry, and microscopy-based tissue analysis.

  • Solid foundation in molecular biology and genetics, including construct design, cloning, RNAi, and CRISPR.

  • Familiarity with single-cell transcriptomics or related high-dimensional platforms is advantageous.

  • Excellent verbal and written communication skills, including the ability to present scientific findings clearly and effectively.

  • Proven ability to complete and communicate scientific projects, as evidenced by at least one peer-reviewed co-first authored publication.

  • Highly organized, self-motivated, and capable of working independently and in cross-functional teams.

  • Needs to be able to maintain detailed laboratory records to be used for potential regulatory filings.

  • Comfortable working with tight timelines and on a milestone-gated project.

  • Biotech industry experience is a plus.
  • Required Skill Profession

    Life Scientists


    • Job Details

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